75000 - Document - Document and Entity Information
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75010 - Statement - Condensed Consolidated Balance Sheets
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75020 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Parenthetical)
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75050 - Statement - Condensed Consolidated Statement of Changes in Convertible Preferred Stock and Stockholders' Equity (Unaudited)
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75060 - Statement - Condensed Consolidated Statements of Cash Flows
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995455 - Disclosure - Nature of the Business
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Business Acquisition
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995485 - Disclosure - Fair Value of Financial Assets
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995495 - Disclosure - Prepaid Expenses and Other Current Assets
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995505 - Disclosure - Investments
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995515 - Disclosure - Property and Equipment, Net
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995525 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets
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995535 - Disclosure - Other Assets
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995545 - Disclosure - Accrued Expenses and Other Current Liabilities
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995555 - Disclosure - Notes Payable
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995565 - Disclosure - Preferred Stock
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995575 - Disclosure - Common Stock
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995585 - Disclosure - Paycheck Protection Loan
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995595 - Disclosure - Lease
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995605 - Disclosure - Restructuring and Other Costs
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995615 - Disclosure - Stock-Based Awards
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995625 - Disclosure - Net Loss per Share
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995635 - Disclosure - Income Taxes
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995645 - Disclosure - Related Party Transactions
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995655 - Disclosure - Commitments and Contingencies
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995665 - Disclosure - Segment Reporting
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995675 - Disclosure - Subsequent Event
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995685 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995695 - Disclosure - Fair Value of Financial Assets (Tables)
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995705 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)
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995715 - Disclosure - Investments (Tables)
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995725 - Disclosure - Property and Equipment, Net (Tables)
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995735 - Disclosure - Other Assets (Tables)
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995745 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)
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995755 - Disclosure - Common Stock (Tables)
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995765 - Disclosure - Stock-Based Awards (Tables)
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995775 - Disclosure - Net Loss per Share (Tables)
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995785 - Disclosure - Commitments and Contingencies (Tables)
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995795 - Disclosure - Segment Reporting (Tables)
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995805 - Disclosure - Nature of the Business - Additional Information (Detail)
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995815 - Disclosure - Summary of Significant Accounting Policies - Additional Information) (Details)
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995825 - Disclosure - Business Acquisition - Additional Information (Detail)
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995835 - Disclosure - Fair Value of Financial Assets - Summary of Assets Measured at Fair Value on Recurring Basis (Detail)
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995845 - Disclosure - Fair Value of Financial Assets - Additional Information (Detail)
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995855 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid and Other Current Assets (Details)
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995865 - Disclosure - Investments - Summary of Fair Value of Available for Sale Investments (Detail)
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995875 - Disclosure - Property and Equipment, Net - Summary of Property and Equipment, Net (Detail)
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995885 - Disclosure - Property and Equipment, Net - Additional Information (Detail)
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995895 - Disclosure - Goodwill and Indefinite-Lived Intangible Assets - Additional Information (Detail)
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995905 - Disclosure - Other Assets - Schedule of Other Assets (Detail)
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995915 - Disclosure - Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail)
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995925 - Disclosure - Notes Payable - Additional Information (Detail)
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995935 - Disclosure - Preferred Stock - Additional Information (Detail)
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995945 - Disclosure - Common Stock - Additional Information (Detail)
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995955 - Disclosure - Common Stock - Schedule of Valuation Assumptions Offering Warrants (Details)
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995965 - Disclosure - Stock-Based Awards - Additional Information (Detail)
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995975 - Disclosure - Stock-Based Awards - Valuation Assumptions of Stock Options Granted (Detail)
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995985 - Disclosure - Stock-Based Awards - Summary of Stock Option Activity (Detail)
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995995 - Disclosure - Stock-Based Awards - Summary of Stock Based Compensation Expense (Detail)
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996005 - Disclosure - Net Loss per Share - Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Detail)
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996015 - Disclosure - Net Loss per Share - Additional Information (Details)
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996025 - Disclosure - Net Loss per Share - Summary of Potential Common Shares Excluded from Calculation of Diluted Net Loss per Share (Detail)
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996035 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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996045 - Disclosure - Commitments and Contingencies - Schedule of Aggregate Future Service and Purchase Commitments with Manufacturer (Details)
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996055 - Disclosure - Segment Reporting - Additional Information (Detail)
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996065 - Disclosure - Segment Reporting - Schedule of Segment Loss, Including Significant Segment Expenses (Detail)
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996075 - Disclosure - Subsequent Event - Additional Information (Detail)
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Preferred Nonconvertible Stock [Member]
Non-convertible preferred stock [Member]
Reversal of stock based compensation expense
Reversal of stock based compensation expense.
Reversal Of Stock Based Compensation Expense
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued, Total
Preferred stock, shares issued
Preferred Stock, Shares Issued
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Securities purchase agreement.
Securities Purchase Agreement [Member]
2021 Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Plan Name
Plan Name [Axis]
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Medical University of South Carolina.
Medical University of South Carolina [Member]
MUSC Agreement [Member]
Proceeds from Warrant Exercises
Net proceeds from warrant exercises
Purchase Agreement [Member]
Purchase Agreement [Member]
Purchase agreement.
Operating expenses:
Operating Expenses [Abstract]
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Initial Pre-Paid Advance Agreement, Second Pre-Paid Advance Agreement and Third Pre-Paid Advance Agreement [Member]
Pre-Paid Advance Agreement, Second Pre-Paid Advance Agreement and Third Pre-Paid Advance Agreement [Member]
Pre-Paid Advance Agreement, Second Pre-Paid Advance Agreement and Third Pre-Paid Advance Agreement
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, shares authorized
Temporary Equity, Par or Stated Value Per Share
Convertible preferred stock, par value
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, Tax
Unrealized gain on investments, tax
Product and Service
Product and Service [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Shell Company
Entity Shell Company
Temporary Equity, Shares Outstanding
Convertible preferred stock, shares outstanding
Contractual Obligation, Total
Aggregate milestones payments
Contractual Obligation
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalent
Cash and cash equivalents at end of period
Cash and cash equivalents at beginning of period
Number of equity compensation plans
Number of equity compensation plans.
Number Of Equity Compensation Plans
Notes payable, net
Notes Payable, Current
Notes Payable, Current, Total
Lung acquisition
Lung Acquisition [Member]
Lung Acquisition [Member]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Assets Disposed of by Sale [Member]
Disposal Group, Disposed of by Sale, Not Discontinued Operations [Member]
Common Stock, Shares, Issued, Total
Common stock, shares issued
Common Stock, Shares, Issued
Short-Term Debt [Table]
Asset Class [Domain]
Statement [Table]
Statement [Table]
Purchase obligation, due in second year and thereafter.
Purchase Obligation Due In Second Year And Thereafter
2025 and thereafter
Weighted average grant-date fair value of stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Schedule of Available-for-Sale Security.
Schedule of Available-for-Sale Security [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Percentage of fair market value of common stock
Statement [Line Items]
Statement [Line Items]
Business Combination [Domain]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Expired
Warrants [Member]
Warrant [Member]
Warrants To Issue Shares Of Common Stock [Member]
Entity Filer Category
Entity Filer Category
Third pre paid advance aggregate amount
Third Pre Paid Advance Aggregate Amount
Third pre paid advance aggregate amount.
Indefinite-lived intangible assets acquired
Business Combination, Recognized Asset Acquired, Identifiable Intangible Asset, Indefinite-Lived
Liabilities and Equity
Total liabilities, convertible preferred stock and stockholders' equity
Payables and Accruals [Abstract]
Weighted Average Exercise Price, Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Business Combination, Voting Equity Interest Acquired, Percentage
Business acquisition, percentage of voting interests acquired
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Harvard and Dana-Farber Agreement [Member]
Harvard And Danafarber Agreement [Member]
Harvard and Dana-Farber agreement.
Shares issued, price per share
Shares Issued, Price Per Share
Subsequent Event [Line Items]
Goodwill, Total
Goodwill, Beginning Balance
Goodwill, Ending Balance
Goodwill
Goodwill
Options Outstanding [Member]
Default interest rate percentage
Default Interest Rate Percentage
Default interest rate percentage.
Earnings Per Share [Table]
Earnings Per Share
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
P I P E Warrants.
P I P E Warrants [Member]
PIPE Warrants [Member]
University of Texas Health Science Center at Tyler Agreement
University of Texas Health Science Center at Tyler Agreement [Member]
UTHSCT Agreement [Member]
Second Pre-Paid Advance Agreement [Member]
Second pre-paid advance agreement
Second Pre-Paid Advance Agreement [Member]
Underlying Asset Class [Domain]
Additional milestones achieved
Number Of Additional Milestones Achieved
Number of additional milestones achieved.
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Fair value of the liabilities
Fair Value of the Liabilities
Fair value of the liabilities
Conversion of Stock, Amount Converted
Conversion of Series X non-voting convertible preferred stock into common stock shares
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Number of Shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of awards granted
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Basic and Diluted Net Loss per Share Attributable to Common Stockholders
Proceeds from Issuance of Preferred Stock and Preference Stock
Proceeds from issuance of preferred stock
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Net loss per share attributable to common stockholders - basic
Net loss per share - basic
Common stock, shares issued, outstanding and reserved for issuance.
Common Stock, Shares Issued, Outstanding and Reserved for Issuance
Shares issued, outstanding and reserved for issuance
Service Agreements [Member]
Service Agreements [Member]
Number of Shares, Beginning balance
Number of Shares, Ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of shares, issued upon exercise of outstanding options
Debt, Policy [Policy Text Block]
Notes Payable
Interest income
Interest Income (Expense), Nonoperating
Total current liabilities
Liabilities, Current
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
PIPE Warrants and Offering Warrants [Member]
PIPE Warrants and Offering Warrants [Member]
PIPE warrants and offering warrants.
LTI Zero Three Program Related Expenses [Member]
Lti zero three program related expenses.
LTI-03 Program-Related Expenses [Member]
Accounting Standards Update [Axis]
Beginning balance
Ending balance
Stockholder Equity Including Convertible Preferred Stock
Stockholder equity including convertible preferred stock.
Stockholders’ equity:
Equity, Attributable to Parent [Abstract]
License and Maintenance [Member]
License and Maintenance [Member]
Entity Small Business
Entity Small Business
Additional liabilities for milestone payments
Liabilities For Additional Milestone Payment
Liabilities for additional milestone payment.
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Other Commitments [Line Items]
Other Commitments [Line Items]
H.C. Wainwright [Member]
H.C. Wainwright.
H.C. Wainwright [Member]
Preferred Stock [Member]
Preferred Stock [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Shares, Forfeited/Canceled
Offering price
Sale of Stock, Price Per Share
Aggregate price per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate intrinsic value of stock options exercised
Aggregate Intrinsic Value, Exercised
Warrants and Rights Outstanding, Measurement Input
Offering warrant valuation
Preclinical Study Costs [Member]
Preclinical study costs.
Preclinical Study Costs [Member]
Stock-Based Awards
Share-Based Payment Arrangement [Text Block]
Leases [Abstract]
Amendment Flag
Amendment Flag
Product and Service
Product and Service [Domain]
Warrant exercisable date
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Initial Pre Paid Advance [Member]
Initial Pre Paid Advance [Member]
Warrants to purchase common stock
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Liabilities and Equity [Abstract]
Liabilities, Convertible Preferred Stock and Stockholders' Equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Additional options grants in period
Share Based Compensation Arrangement By Share Based Payment Award Additional Options Grants In Period
Share based compensation arrangement by share based payment award additional options grants in period.
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
LTI Zero One Program Related Expenses [Member]
Lti zero one program related expenses.
LTI-01 Program-Related Expenses [Member]
Common Stock [Member]
Common Stock [Member]
Offering Shares [Member]
Clinical Operation Activities [Member]
Clinical operation activities.
Clinical Operation Activities [Member]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
Exercise price
Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Less: Accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Amortization of Debt Discount (Premium)
Amortization of debt discount recognized as interest expense
Net amortization of discount on notes payable
Schedule of Available-for-sale Securities [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Entity Address, Address Line One
Entity Address, Address Line One
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Valuation Assumptions of Stock Options Granted
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Wainwright Sales Agreement.
Wainwright Sales Agreement [Member]
Wainwright Sales Agreement [Member]
Level 2 [Member]
Fair Value Hierarchy and NAV [Axis]
Earnings Per Share [Abstract]
Second Pre Paid Advance Average Price Per Share
Second pre paid advance average price per share.
Second pre paid advance average price per share
Temporary Equity, Carrying Amount, Attributable to Parent
Beginning balance
Ending balance
Convertible preferred stock, $0.001 par value, 5,000,000 shares authorized at March 31, 2026 and at December 31, 2025; 24,610 shares issued and 12,232 shares outstanding at March 31, 2026 and at December 31, 2025
Preferred stock, convertible, shares issuable beneficial ownership as a percentage.
Preferred Stock, Convertible, Shares Issuable Beneficial Ownership As A Percentage
Preferred stock, convertible, shares issuable beneficial ownership as a percentage
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Transactions
Business acquisition cash in lieu of fractional shares.
Business Acquisition Cash in Lieu of Fractional Shares
Business acquisition cash in lieu of fractional shares
Contract obligation, prepaid amount
Contract obligation, prepaid amount.
Contract Obligation Prepaid Amount
Goodwill and Intangible Assets Disclosure [Text Block]
Goodwill and Indefinite-Lived Intangible Assets
Investment Type
Investment Type [Axis]
Percentage of Original Issue Discount
Percentage of original issue discount
Original issue discount
Changes in operating assets and liabilities:
Increase (Decrease) in Other Operating Assets and Liabilities, Net [Abstract]
Class of Warrant or Right [Axis]
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
Entity Central Index Key
Summary of Fair Value of Available for Sale Investments
Debt Securities, Available-for-Sale [Table Text Block]
Issuance of common stock in connection with conversion of Series X preferred stock
Temporary Equity, Conversion of Stock, Value
Temporary equity, conversion of stock, value.
Investments, Debt and Equity Securities [Abstract]
Restructuring and other costs (Note 8)
Accrued restructuring balance
Restructuring Reserve, Current
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net increase (decrease) in cash and cash equivalents
Subsequent Event Type [Domain]
Potential common shares excluded from calculation of diluted net loss per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Disposal Group Classification [Domain]
Short-Term Debt [Text Block]
Notes Payable
Business Combination, Consideration Transferred, Equity Interest, Type [Domain]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Accounting Standards Update [Domain]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total other comprehensive loss
Proceeds from Issuance of Warrants
Proceeds from the PIPE transaction
Initial Fair Value of Warrants Issued
Initial fair value of warrants issued.
Initial fair value of warrants issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term, Outstanding
Investments, Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Second Pre Paid Advance Aggregate Amount
Second pre paid advance aggregate amount.
Second pre paid advance aggregate amount
Number of stock options exercised
Number of Shares, Exercised
Exercise of stock options, shares
Number of Shares, Exercised
Debt Disclosure [Abstract]
Accounting Standards Update 2024-01 [Member]
Accounting standards update 2024-01.
ASU 2024-01 [Member]
Third Pre Paid Advance Average Price Per Share
Third pre paid advance average price per share.
Third pre paid advance average price per share
Debt Instrument Purchase Price
Debt instrument purchase price.
Debt instrument purchase price
Current Fiscal Year End Date
Current Fiscal Year End Date
Document Quarterly Report
Document Quarterly Report
Increase In Common Stock
Increase In Common Stock
Increase in common stock
Fair Value By Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Entity Address, State or Province
Entity Address, State or Province
Stock Issued During Period, Value, Conversion of Convertible Securities
Issuance of common stock,Value
Issuance of common stock in connection with conversion of Series X preferred stock
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase decrease in operating lease liabilities.
Underwriting agreement
Underwriting Agreement [Member]
Underwriting Agreement [Member]
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Beginning balance, shares
Ending balance, shares
Total comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Investments, Gross Unrealized Gain
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Stock reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for issuance
Class of Warrant or Right [Domain]
Series X Preferred Stock [Member]
Series X preferred stock.
Series X Preferred Stock [Member]
Conversion of Stock, Shares Converted
Conversion of stock shares converted
Project Addendum [Member]
Project addendum.
Project Addendum [Member]
Prepaid research and development
Prepaid research and development
Prepaid Research And Development
Fair Value of Warrants Replaced
Fair value of warrants replaced.
Fair value of warrants replaced
Payments for royalties
Payments for Royalties
License [Member]
License [Member]
Summary of Stock Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Accrued Expenses and Other Current Liabilities
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Commitment fee under SEPA
Commitment Fee
Commitment fee.
Restricted stock units vested but unsettled
Sharebased Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested But Not Issued In Period
Sharebased Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested But Not Issued In Period
Vested, not issued
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive loss:
Subsequent Event [Member]
Pre-Funded Warrants [Member]
Pre Funded Warrants [Member]
Pre funded warrants.
Property, Plant and Equipment [Abstract]
Increase to shares authorized for issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Other non-current assets
Other Assets, Noncurrent
Total other non-current assets
Fair Value Measurement Inputs and Valuation Techniques [Table]
Expected term (in years)
Measurement Input, Expected Term [Member]
Debt Securities, Available-for-sale, Current, Total
Investments, Fair Value
Investments
Debt Securities, Available-for-Sale, Current
Preferred Stock, Dividends, Per Share, Cash Paid
Preferred stock, dividends paid
Antidilutive Securities
Antidilutive Securities [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Number of Shares, Expired
Number of Shares, Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Vesting percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Options vested and expected to vest
Earnings Per Share [Line Items]
Earnings Per Share
Initial Pre Paid Advance Aggregate Amount
Initial pre paid advance aggregate amount.
Initial pre paid advance aggregate amount
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss [Member]
Goodwill, Impairment Loss
Impairment of goodwill
License fee on agreement effective date
License fee on agreement effective date
License Fee on Agreement Effective Date
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Other Commitments [Table]
Other Commitments [Table]
Employee Related Expenses [Member]
Employee related expenses.
Employee Related Expenses [Member]
Percentage of Warrants Purchase of Common Stock Sold
Percentage of warrants purchase of common stock sold.
Percentage of warrants to purchase on common stock sold in offering
Business Acquisition, Equity Interest Issued or Issuable, Value Assigned
Business Combination, Consideration Transferred, Equity Interest, Share Issued, Value
Debt instrument, maturity date
Debt Instrument, Maturity Date
Therapeutic Product [Member]
Therapeutic Product [Member]
Therapeutic product.
Minimum [Member]
Minimum [Member]
Financial Instrument [Axis]
Current assets:
Assets, Current [Abstract]
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Segment Reporting [Abstract]
Preferred stock, dividends declared
Preferred Stock, Dividends Per Share, Declared
Summary of Assets Measured at Fair Value on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Standby Equity Purchase Agreement [Member]
Standby Equity Purchase Agreement.
Restructuring and Other Costs
Restructuring and Related Activities Disclosure [Text Block]
Debt Conversion, Original Debt, Interest Rate of Debt
Original issue discount percent
Related Party Transactions [Abstract]
Business Combination, Consideration Transferred, Equity Interest, Type [Axis]
Commitments and Contingencies
Commitments and contingencies (Note 13)
Vivarta therapeutics LLC
Vivarta Therapeutics LLC [Member]
Number of Maximum Patient for Trial
Number of maximum patient for trial.
Number of patients
Fully Depreciated Assets [Member]
Fully Depreciated Assets [Member]
Fully depreciated assets.
General and Administrative [Member]
General and Administrative Expense [Member]
Indefinite-Lived Intangible Assets [Line Items]
2024 Warrants [Member]
Two Thousand Twenty Four Warrants [Member]
Two Thousand Twenty Four Warrants.
Treasury Bills [Member]
US Treasury Bill Securities [Member]
Other
Other Accruals And Other Current Liabilities
Other accruals and other current liabilities.
April 2025 Transactions [Member]
April Two Thousand and Twenty Five Transactions [Member]
April two thousand and twenty five transactions.
Pre-Paid Advances Amount
Pre-paid advances amount.
Maximum amount available for pre-paid advances
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Warrant Exercises [Member]
Warrant Exercises [Member]
Warrant exercises.
Long-Term Debt, Type [Domain]
Weighted average common shares outstanding - basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Scenario [Axis]
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Debt Instrument Original Issue Discount Percentage
Debt instrument original issue discount percentage.
Percent of original issue debt discount
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Options exercisable
Common warrants.
Common Warrants [Member]
Common Warrants [Member]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures
Shares granted in consideration
Subsequent Events [Text Block]
Subsequent Event
Letter Agreement With Bios Partners [Member]
Letter agreement with Bios Partners.
Letter agreement with Bios Partners, L.P. [Member]
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Equity, Attributable to Parent
Equity, Attributable to Parent, Total
Beginning balance
Ending balance
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Unaudited Interim Financial Information
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Statement of Stockholders' Equity [Abstract]
Corporate Notes [Member]
Corporate Note Securities [Member]
Whole Share.
Whole Share [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Minimum Gross Proceeds from Qualifying Financing Transaction for Debt Closing
Minimum gross proceeds from qualifying financing transaction for debt closing.
Minimum gross proceeds from qualifying financing transaction for debt closing
Equity issuance price as percentage of volume weighted average price
Equity Issuance Price as Percentage of Volume Weighted Average Price
Equity issuance price as percentage of volume weighted average price.
Over-Allotment Option [Member]
Option Given to Underwriter to Purchase Additional Shares
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value of Financial Assets
Fair Value Disclosures [Text Block]
Summary of Stock Option Activity
Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block]
CMC Activities [Member]
Cmc activities.
CMC Activities [Member]
Summary of Accrued Expenses and Other Current Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Other Assets, Current
Other current assets
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Total accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Accrued Liabilities and Other Liabilities
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Plan Name
Increase (Decrease) in Other Operating Assets, Total
Other assets
Increase (Decrease) in Other Operating Assets
Fair value of warrants issued
Fair Value of Warrants Issued
Fair value of warrants issued.
Interest expense
Interest Expense, Operating and Nonoperating
Interest Expense, Operating and Nonoperating, Total
Pre Paid Advances Term
Pre paid advances term.
Pre-paid advances term
Cost of Goods and Services Sold, Total
Annual license maintenance fees
Cost of Product and Service Sold
Structuring and Legal Fees
Structuring and legal fees.
Structuring and Legal Fees
Business Description and Basis of Presentation [Text Block]
Nature of the Business
Existing Equity Incentive Plans [Member]
Equity incentive plans.
Equity Incentive Plans [Member]
Net Proceeds From Warrant Exchanges
Net proceeds from warrant exchanges.
Net proceeds from warrant exchanges
Entity Address, City or Town
Entity Address, City or Town
Number of Reportable Segments
Number of reportable segment
Security Exchange Name
Security Exchange Name
Prepaid Expense and Other Assets [Abstract]
Operating Lease Agreements [Member]
Operating Lease Agreement [Member]
Operating Lease Agreement [Member]
Property and equipment, gross
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross
Offering Warrant Shares.
Offering Warrant Shares [Member]
Offering Warrant Shares [Member]
Warrants to purchase shares of common stock
Warrants to Purchase Shares of Common Stock
Warrants to purchase shares of common stock
Counterparty Name [Axis]
Diagnostic Product [Member]
Diagnostic Product [Member]
Diagnostic product.
Number of Shares, Options vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Measurement Input Type [Domain]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Pre-Paid Advance Agreement [Member]
Pre-Paid Advance Agreement.
Pre-Paid Advance Agreement [Member]
Warrants to Purchase Shares of Common Stock Remained Outstanding
Warrants to purchase shares of common stock remained outstanding.
Warrants to purchase shares of common stock remained outstanding
Statistical Measurement
Statistical Measurement [Domain]
OID costs
Original Issue Discount Costs
Original issue discount costs.
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants exercise price
Warrant per share
Total current assets
Assets, Current
Recognized stock-based compensation expense
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Document Period End Date
Document Period End Date
Yorkville Transactions [Member]
Yorkville Transactions.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Number of Shares, Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax
Foreign currency translation adjustments
Impairment of indefinite-lived intangible assets
Impairment of Intangible Assets, Indefinite-Lived (Excluding Goodwill)
Other Assets, Miscellaneous, Noncurrent
Other assets
Gain (Loss) on Disposition of Property Plant Equipment, Total
Gain on sale of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Gain (loss) on sale of property and equipment
Loss on disposition of property and equipment
Statement of Financial Position [Abstract]
Restricted Stock Units [Member]
Restricted Stock Units (RSUs) [Member]
Initial pre paid advance average price per share
Initial Pre Paid Advance Average Price Per Share
Initial pre paid advance average price per share.
Equity Distribution Agreement [Member]
Equity Distribution Agreement [Member]
Equity Distribution Agreement [Member]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Adjustment changes in fair value
Adjustment for Changes in Fair Value
Adjustment for changes in fair value
Class of Stock
Class of Stock [Axis]
Second Pre Paid Advance [Member]
Second Pre Paid Advance [Member]
Warrants and Rights Outstanding, Maturity Date
Warrants and rights outstanding, maturity date
Commercial Paper [Member]
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Total liabilities
Liabilities
Share based compensation arrangement by share based payment award number of remaining options outstanding shares available for future issuance.
Number of shares remained available for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Remaining Options Outstanding Shares Available For Future Issuance
Financial Instruments [Domain]
Principal from Pre-Paid Advances
Principal from pre-paid advances.
Principal received from pre-paid advances
Measurement Input, Exercise Price [Member]
Exercise price
Stock incentive plan description
Share-Based Compensation Arrangement by Share-Based Payment Award, Description
Pre-paid advance annual rate
Annual Rate of Pre-Paid Advances
Annual rate of pre-paid advances.
Restricted cash at end of period
Restricted Cash, Total
Restricted Cash
Prepaid Expense and Other Assets, Current [Abstract]
Weighted average common shares outstanding - diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Entity File Number
Securities Act File Number
Unrealized gain on short-term investments
Unrealized loss on investments, net of tax of $0
Unrealized loss on short-term investments
Accounting Standards Update 2023-07 [Member]
ASU 2023-07 [Member]
Cover [Abstract]
Merger Agreement.
Merger Agreement [Member]
Measurement Input Type [Axis]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total prepaid expenses and other current assets
Investments
Investments [Domain]
Foreign currency translation adjustments
Foreign Currency Translation Adjustments
Foreign Currency Translation Adjustments
Scenario [Domain]
Series X Non-Voting Convertible Preferred Stock [Member]
Series X Non-Voting Convertible Preferred Stock.
Series X Non-Voting Convertible Preferred Stock [Member]
Bios Pre-Funded Warrants [Member]
Bios Pre-Funded Warrants [Member]
Bios Pre-Funded Warrants.
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Segment Reporting
Segment Reporting Disclosure [Text Block]
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
General and administrative expenses
Business Combination, Asset Acquisition, Transaction between Entities under Common Control, and Joint Venture Formation [Abstract]
Subsequent Event [Table]
Short-Term Debt, Type [Domain]
Adjustments to Additional Paid in Capital, Warrant Issued
Issuance of warrants
Issuance of common stock warrant
Issuance of common stock warrant
Issuance of Common Stock Warrant
Underwriting Discounts, Commissions, And Offering Expenses
Underwriting discounts, commissions, and offering expenses.
Underwriting discounts, commissions, and offering expenses
Weighted Average Exercise Price, Options vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Restructuring charges
Restructuring Charges
Restructuring Charges, Total
Restructuring and other costs
Short-Term Debt, Type [Axis]
New Accounting Pronouncements, Policy [Policy Text Block]
Accounting Pronouncements Not Yet Adopted
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Issuance of common stock in connection with conversion of Series X preferred stock, shares
Stock Issued During Period, Shares, Conversion of Convertible Securities
Stock option granted vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Depreciation, Total
Depreciation and amortization expense
Depreciation
Common stock, shares outstanding
Beginning balance, shares
Ending balance, shares
Number of shares owned
Depreciation, Depletion and Amortization, Total
Depreciation and amortization expense
Depreciation, Depletion and Amortization
Contractual Obligation, Fiscal Year Maturity [Table Text Block]
Schedule of Aggregate Future Service and Purchase Commitments with Manufacturer
Document Transition Report
Document Transition Report
Total operating expenses
Operating Expenses
Research and Development Expense, Total
Research and development
Research and Development Expense
Research and development expenses
Gross proceeds from issuance of preferred stock
Gross proceeds from issuance of preferred stock.
Gross Proceeds from Issuance of Preferred Stock
Lease
Lessee, Operating Leases [Text Block]
Statement of Cash Flows [Abstract]
Umicore Agreement [Member]
Umicore Agreement [Member]
Umicore agreement.
Warrants to purchase shares of common stock exercised
Warrants to Purchase Shares of Common Stock Exercised
Warrants to purchase shares of common stock exercised.
Stock issued during period, value
Stock Issued During Period, Value, New Issues
Issuance of common stock
Payments to Acquire Businesses, Net of Cash Acquired, Total
Payments to Acquire Businesses, Net of Cash Acquired
Net proceeds from the PIPE Financing expected to continue to be used to advance
Common Stock
Equity [Text Block]
Net Loss per Share
Earnings Per Share [Text Block]
Expected dividend yield
Measurement Input, Expected Dividend Rate [Member]
Summary of Restricted Stock Unit Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Net loss
Net loss
Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Ending balance
Aggregate Intrinsic Value, Beginning balance
Preferred Stock, Convertible, Shares Issuable
Preferred Stock is convertible into common stock
Cash consideration
Issuance of Exchange Pre Funded Warrants for Cash Consideration
Issuance of exchange pre funded warrants for cash consideration
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Intangible Assets, Net (Excluding Goodwill), Total
Intangible Assets, Net (Excluding Goodwill)
Intangible assets
Purchase Obligation
Non-cancellable purchase obligations
Total purchase commitments
2006 Stock Incentive Plan [Member]
Two Thousand Six Stock Incentive Plan [Member]
Two thousand six stock incentive plan.
Assets
Assets [Abstract]
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
2023 Warrants [Member]
Two Thousand Twenty Three Warrants [Member]
Two Thousand Twenty Three Warrants.
Third Pre-Paid Advance Agreement [Member]
Third pre-paid advance agreement
Third Pre-Paid Advance Agreement [Member]
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Aggregate fair value of stock options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Research and Development [Member]
Research and Development Expense [Member]
Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
2017 Stock Incentive Plan [Member]
Two Thousand Seventeen Stock Incentive Plan [Member]
Two thousand seventeen stock incentive plan.
Number of shares remained available for grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Remaining Shares Available For Grant
Share based compensation arrangement by share based payment award number of remaining shares available for grant.
Debt Conversion, Converted Instrument, Amount
Debt conversion, converted instrument, amount
2024
Purchase Obligation, to be Paid, Year One
Proceeds from Stock Options Exercised
Proceeds from issuance of common stock in connection with stock option exercises
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Stock price
Measurement Input, Share Price [Member]
Consecutive Trading Days
Consecutive trading days.
Consecutive trading days
Intangible Asset, Indefinite-Lived [Table]
Proceeds from sales of stock
Gross proceeds from common stock shares issued and sold
Net proceeds from the offering
Citizens JMP Securities [Member]
Citizens JMP Securities [Member]
Citizens Jmp Securities [Member]
Citizens JMP Securities [Member]
Available-for-sale investments, maximum contractual maturity period
Available For Sale Investments Maximum Contractual Maturity Period
Available-for-sale investments, maximum contractual maturity period.
Share-Based Payment Arrangement [Abstract]
Noncurrent prepaid research and development
Noncurrent Prepaid Research And Development
Non-current prepaid research and development
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Aggregate unrecognized stock-based compensation expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Total Fair Value of Financial Instruments
Assets, Fair Value Disclosure
Sale of Stock
Sale of Stock [Axis]
Private Placement [Member]
Private Placement [Member]
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Entity Address, Address Line Three
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Forfeited/Canceled
Money Market Funds [Member]
Money Market Funds [Member]
Income Tax Disclosure [Text Block]
Income Taxes
Convertible preferred stock, shares issued
Temporary Equity, Shares Issued
Percentage of common stock shares outstanding
Percentage Common Stock Outstanding Shares
Percentage common stock outstanding shares.
Maximum annual increase in common stock reserved for future issuance.
Maximum Annual Increase In Common Stock Reserved For Future Issuance
Maximum annual increase in common stock reserved for future issuance
Other long-term liability
Other Liabilities, Noncurrent
Percentage of discount to per share price
Percentage of discount to per share price.
Percentage Of Discount To Per Share Price
Summary of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Weighted Average Exercise Price, Beginning balance
Weighted Average Exercise Price, Ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Preferred Stock [Text Block]
Preferred Stock
2016 Stock Incentive Plan [Member]
Two Thousand Sixteen Stock Incentive Plan [Member]
Two thousand sixteen stock incentive plan.
License fee on receipt of positive freedom to operate analysis from legal counsel
License Fee on Receipt of Positive Freedom to Operate Analysis From Legal Counsel
License fee on receipt of positive freedom to operate analysis from legal counsel
Income Tax Disclosure [Abstract]
Lung therapeutics, inc.
Lung Therapeutics, Inc. [Member]
Lung Acquisition [Member]
Initial Pre-Paid Advance Amount
Initial pre-paid advance amount.
Initial pre-paid advance
Business Combination [Text Block]
Business Acquisition
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Accrued expenses and other current liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Measurement Frequency
Measurement Frequency [Domain]
Income Statement Location
Statement of Income Location, Balance [Axis]
2017 Employee Stock Purchase Plan [Member]
Two Thousand Seventeen Employee Stock Purchase Plan [Member]
Two thousand seventeen employee stock purchase plan.
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Second Pre Paid Advance Amount
Second pre paid advance amount.
Second pre-paid advance
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Proceeds from Notes Payable
Proceeds from Notes Payable, Total
Notes payable, net
Net proceeds from notes payable
Subsequent Event Type [Axis]
Two thousand thirteen stock incentive plan.
Two Thousand Thirteen Stock Incentive Plan [Member]
2013 Stock Incentive Plan [Member]
Employee-related Liabilities, Current, Total
Payroll and payroll-related costs
Employee-related Liabilities, Current
Cash flows from financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Recurring [Member]
Fair Value, Recurring [Member]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Third Pre Paid Advance Amount
Third pre paid advance amount.
Third pre-paid advance
Schedule of prepaid and other current assets.
Schedule of Prepaid and Other Current Assets [Table Text Block]
Schedule of Prepaid and Other Current Assets
Equity Components
Equity Components [Axis]
Equity Component
Equity Component [Domain]
Asset Class [Axis]
Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets
Prepaid Expenses And Other Current Assets [Text Block]
Goodwill and Intangible Assets Disclosure [Abstract]
Third Pre Paid Advance [Member]
Third Pre Paid Advance [Member]
Business Combination [Axis]
Stock option expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
YA II PN Ltd.
YA II PN Ltd [Member]
YA II PN Ltd [Member]
Common Stock, Voting Rights
Common stock voting rights
Maximum [Member]
Maximum [Member]
Statistical Measurement
Statistical Measurement [Axis]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Aggregate offering price
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Common stock, $0.001 par value; 100,000,000 shares authorized at March 31, 2026 and at December 31, 2025; 28,039,032 shares and 27,550,222 shares issued and outstanding at March 31, 2026 and December 31, 2025, respectively
External research and development services
Accrued External Research And Development Services Current
Accrued external research and development services current.
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Comprehensive loss:
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Professional Fees For Services [Member]
Professional fees for services.
Professional Fees for Services [Member]
Net proceeds received from pre-paid advance
Net Proceeds from Pre-Paid Advances
Net proceeds from pre-paid advances.
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Royalty Expense
Minimum royalty fee
Proceeds from collaboration agreement
Proceeds from Collaborators
Underlying Asset Class [Axis]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Stock Options.
Stock Options [Member]
Business Combination [Table]
Net effect modification of warrants issued
Net Effect Modification of Warrants Issued
Net effect modification of warrants issued.
Entity Registrant Name
Entity Registrant Name
Gross Proceeds from Issuance of Common Stock
Gross proceeds from issuance of common stock.
Gross proceeds from offering
Scenario Two [Member]
Scenario two.
Investments, Gross Unrealized Loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net, Total
Fair Value, assets transfers into (out of) Level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net
Unsecured Promissory Notes [Member]
Unsecured Promissory Notes [Member]
Unsecured promissory notes.
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income, net
Other (expense) income, net
Unamortized portion of debt discount
Debt Instrument, Unamortized Discount, Current
Conversion of stock shares issued
Conversion of Stock, Shares Issued
Subsequent Events [Abstract]
Other Assets Disclosure [Text Block]
Other Assets
Paycheck Protection Loan
Paycheck Protection Loan C A R E S Act [Text Block]
Paycheck protection loan CARES Act.
Recurring [Member]
Measurement Frequency [Axis]
Milestone payments
Payments For Milestone
Payments for milestone.
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock, net of offering costs
Net proceeds from offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Schedule of Valuation Assumption Offering Warrants
Common Stock and Series X Preferred Stock [Member]
Common Stock and Series X Preferred Stock.
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Facilities And Other Expenses [Member]
Facilities and other expenses.
Facilities and Other Expenses [Member]
Disposal Group Classification [Axis]
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Computer Equipment and Software [Member]
Computer Equipment And Software [Member]
Computer equipment and software.
Number of units granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Share based compensation arrangement by share based payment award outstanding options.
Share Based Compensation Arrangement By Share Based Payment Award Outstanding OptionsOutstanding
Number of shares outstanding options
Cost of asset
Total assets
Assets
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Weighted Average Remaining Contractual Term, Options exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Income Statement [Abstract]
At the market offering.
At The Market Offering [Member]
At The Market Offering [Member]
Legal costs
Legal Fees
Aggregate number of common stock shares issued and sold
Sale of Stock, Number of Shares Issued in Transaction
Number of stock sold
Stock Issued During Period, Shares, New Issues
Issuance of common stock in connection with conversion of Series X preferred stock, shares
Issuance of common stock, shares
Temporary Equity, Shares Authorized
Convertible preferred stock, shares authorized
Number of units vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Net loss per share attributable to common stockholders - diluted
Net loss per share - diluted
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Segment Loss, Including Significant Segment Expenses
City Area Code
City Area Code
Series X Preferred Stock Issued And Outstanding, As Converted [Member]
Series X preferred stock issued and outstanding, as converted.
Series X Preferred Stock Issued And Outstanding, As Converted [Member]
Exchange Pre-Funded Warrants [Member]
Exchange Pre-Funded Warrants [Member]
Exchange pre-funded warrants.
Pre Paid Advances Purchase Price Percentage
Pre paid advances purchase price percentage.
Pre-paid advances purchase price percentage
Debt Instrument, Face Amount
Original principal amount
Aggregate principal amount
Business Combination [Line Items]
Counterparty Name [Domain]
Segment Reporting Information [Line Items]
Lease termination date
Lease Expiration Date
Lease expiration date
Modified Scope of Agreement [Member]
License Agreement Terms [Member]
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Property and equipment, net
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property and equipment, net
Property, Plant and Equipment, Net
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash and cash equivalents at beginning of period
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Loss from operations
Operating Income (Loss)
First and Second Pre-Paid Advance Agreement [Member]
First And Second Pre-Paid Advance Agreement [Member]
First and second pre-paid advance agreement.
Accumulated Deficit [Member]
Retained Earnings [Member]
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Measurement Input, Price Volatility [Member]
Expected volatility
Discounts, commissions and offering expenses
Payments of Stock Issuance Costs
Issuance costs
Contractual repurchase right, shares
Share Repurchase Program, Authorized, Number of Shares
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Class of Stock [Line Items]
Class of Stock [Line Items]
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Short-Term Debt [Line Items]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Deferred Income Tax Liabilities, Net
Deferred tax liability
Reduced aggregate offering price
Reduced Aggregate Offering Price
Reduced aggregate offering price.
Fractional share.
Fractional Share [Member]
Summary of Potential Common Shares Excluded from Calculation of Diluted Net Loss per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Convertible promissory notes.
Convertible Promissory Notes [Member]
Income Statement Location
Statement of Income Location, Balance [Domain]
Cash flows from operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Preferred Stock is automatically convertible into common stock
Convertible Preferred Stock, Shares Issued upon Conversion
Preferred stock convertible into common stock
Scenario One [Member]
Scenario one.
Aggregate number of shares issued and sold
Business Combination, Consideration Transferred, Equity Interest, Share Issued, Number of Shares
Business Acquisition, Equity Interest Issued or Issuable, Number of Shares
Increase (Decrease) in Other Noncurrent Liabilities
Other long-term liabilities
Business acquisition number of shares exercisable.
Business Acquisition Number Of Shares Exercisable
Business acquisition number of shares exercisable
Common Stock, Dividends, Per Share, Declared
Common stock, dividends declared
Entity Tax Identification Number
Entity Tax Identification Number
Contractual terms of stock option awards
Share based compensation arrangement by share based payment award, contractual terms of award.
Share Based Compensation Arrangement by Share Based Payment Award, Contractual Terms of Award
Long-Term Debt, Type [Axis]
Underwritten Public Offering [Member]
Underwritten public offering.
Underwritten Public Offering [Member]
Local Phone Number
Local Phone Number
Transaction fee
Transaction Fee
Transaction fee.
Fully Settled Remaining Outstanding Balance
Fully settled remaining outstanding balance
Remaining outstanding balance
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
2021 Stock Incentive Plan [Member]
Two Thousand Twenty One Stock Incentive Plan [Member]
Two thousand twenty one stock incentive plan.
Other Program Related Expenses [Member]
Other program related expenses.
Other Program-Related Expenses [Member]
Accounting Policies [Abstract]
Short-Term Debt, Terms
Short-term debt terms
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Temporary Equity, Conversion of Stock, Shares
Temporary equity, conversion of stock, shares.
Issuance of common stock in connection with conversion of Series X preferred stock, shares
Schedule of Other Assets, Noncurrent [Table Text Block]
Schedule of Other Assets
Class of Stock
Class of Stock [Domain]
Number of shares, available for grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Stock remained available for future issuance
Unrecognized stock-based compensation expense, weighted average period expects for recognition
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Professional fees
Accrued Professional Fees, Current
Schedule Of Stock By Class [Table]
Stock, Class of Stock [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Weighted Average Remaining Contractual Term, Options vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Area of land
Area of Land