United States securities and exchange commission logo August 17, 2020 Manuel C. Alves Aivado, M.D., Ph.D. President and Chief Executive Officer Aileron Therapeutics, Inc. 490 Arsenal Way, Suite 210 Watertown, MA 02472 Re: Aileron Therapeutics, Inc. Registration Statement on Form S-3 Filed August 11, 2020 File No. 333-244367 Dear Dr. Aivado: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jeffrey Gabor at 202-551-2544 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Stuart M. Falber, Esq.